The DSL ligand APX-1 is required for normal ovulation in C. elegans
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منابع مشابه
URI-1 is required for DNA stability in C. elegans.
Unconventional prefoldin RPB5 interactor (URI), an evolutionary conserved member of the prefoldin family of molecular chaperones, plays a central role in the regulation of nutrient-sensitive, TOR (target-of-rapamycin)-dependent gene expression programs in yeast. Mammalian URI has been shown to associate with key components of the transcriptional machinery, including RPB5, a shared subunit of al...
متن کاملemo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation
emo-1(oz1) is a member of a class of hermaphrodite sterile mutations in Caenorhabditis elegans that produce endomitotic oocytes in the gonad arm. Oocytes in emo-1(oz1) mutants exhibit multiple defects during oogenesis. After meiotic maturation, ovulation fails, trapping oocytes in the gonad arm where they become endomitotic. emo-1 encodes a homologue of the Sec61p gamma subunit, a protein neces...
متن کاملifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans.
Large cytoplasmic ribonucleoprotein germ granule complexes are a common feature in germ cells. In C. elegans these are called P granules and for much of the life-cycle they associate with nuclear pore complexes in germ cells. P granules are rich in proteins that function in diverse RNA pathways. Here we report that the C. elegans homolog of the eIF4E-transporter IFET-1 is required for oogenesis...
متن کاملThe ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans
Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway. Guanine nucleotide exchange factor (GEFs) activate the small GTPases and help their anchorage in the membrane. Thus, GEFs in a way temporally and spatially control Sar1/Arf1 GTPase activation. We investigated the role of the ArfGEF GBF-1 in C...
متن کاملThe DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans.
Vasa and Belle are conserved DEAD box RNA helicases required for germ cell function. Homologs of this group of proteins in several species, including mammals, are able to complement a mutation in yeast (DED1) suggesting that their function is highly conserved. It has been proposed that these proteins are required for mRNA translation regulation, but their specific mechanism of action is still u...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2018
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2018.01.009